HCID 58659424, compound → 1-[4-(6-Amino-pyrimidin-4-ylmethyl)-phenyl]-3-p-tolyl-urea

HRID 1993594Notes

Reaction equation

HRID 1993594 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25]C)=[CH:21][CH:20]=3)=[O:17])=[CH:11][CH:10]=2)[CH:3]=1>CN(C=O)C>[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH:15][C:16]([NH:18][C:19]3[CH:20]=[CH:21][C:22]([CH3:25])=[CH:23][CH:24]=3)=[O:17])=[CH:13][CH:14]=2)[CH:3]=1

Participants

3

Reactant 1

HCID 58659424HCID 58659424, compound

Product 1

HCID 586593761-[4-(6-Amino-pyrimidin-4-ylmethyl)-phenyl]-3-p-tolyl-urea

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared as described in Example 102 but using 6-(4-aminobenzyl)-pyrimidin-4-ylamine (see Example 157), and DMF as the solvent. The reaction mixture is stirred for 3 h. The title compound is obtained as a white solid: ES-MS: 348.0 [M+H]+; single peak at tR=6.94 min (System 2).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-db61654a5b4448e89f12d4369de5083f
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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