反应详情

A solution of compound 6d (43.5 g) in anhydrous DMF (150 mL) was cooled to 5° C. To this solution was added potassium phthalimide (26.1 g, 141 mmol). After 5 min the cooling bath was removed and the reaction was allowed to stir at RT for 3 hr. The solvent was evaporated under vacuum to provide a tan solid. The solid was rinsed with 4:1 DCM/methanol and then water. The filter cake was slurried in toluene and evaporated to dryness to afford 4′-bromo-2′-methoxy-2-(phthalimido)acetophenone (compound 6e, 39 g) as a tan solid.

1. customAfter 5 min the cooling bath was removed
2. customThe solvent was evaporated under vacuum
3. customto provide a tan solid
4. washThe solid was rinsed with 4:1 DCM/methanol
5. customevaporated to dryness