Ethylenethiourea → HCID 68537668, compound

HRID 1993912Notes

Reaction equation

HRID 1993912 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][Br:7])=[C:4]([F:10])[CH:3]=1.[CH2:11]1[NH:16][C:14](=[S:15])[NH:13][CH2:12]1>C(#N)C>[BrH:7].[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:15][C:14]2[NH:16][CH2:11][CH2:12][N:13]=2)=[C:4]([F:10])[CH:3]=1

Participants

4

Reactant 2

HCID 2723650EthylenethioureaHCID 27365514-Chloro-2-fluorobenzyl bromide

Product 1

HCID 68537668HCID 68537668, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 4-chloro-2-fluorobenzylbromide (0.223 g, 1.0 mmol) and N,N′-ethylene thiourea (0.102 g, 1.0 mmol) in acetonitrile (4.5 ml) was heated for 10 min to 110° C. by microwave irradiation. After cooling down to room temperature a solid precipitated that was removed by filtration and washed with ether. It was obtained 260 mg (80%) of a white solid; MS (ISP): 245.0; 247.0 ([M+H]+.).

Workup

  1. temperaturewas heated for 10 min to 110° C. by microwave irradiation
  2. customprecipitated that
  3. customwas removed by filtration
  4. washwashed with ether

Sources & evidence

ORD record
ord-9797cd69a7e2466096fc6fe27b9bcac8
Source dataset
uspto-grants-2010_01
Patent number
US07652055B2

Reaction notes

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