反应详情

温度

100 °C

To a solution of methyl-3-cyclopropyl-3-oxopropionate (10 g) and acetic acid (28 mL) in a round bottom flask under argon was added hydrazine hydrate (2.25 g). The mixture was immersed into an oil bath and heated to 100° C. overnight. The reaction vessel was then cooled and the acetic acid was evaporated in vacuo and the remaining solid was added to 1 N aqueous sodium hydroxide solution. The resulting precipitate was collected by filtration and washed with water and cold ether to afford the desired 5-cyclopropyl-2,4-dihydro-pyrazol-3-one (8.2 g) as a beige solid.

1. customThe mixture was immersed into an oil bath
2. temperatureThe reaction vessel was then cooled
3. customthe acetic acid was evaporated in vacuo
4. additionthe remaining solid was added to 1 N aqueous sodium hydroxide solution
5. filtrationThe resulting precipitate was collected by filtration
6. washwashed with water and cold ether