Methyl iodide → HCID 16063636, compound

HRID 1993938Notes

Reaction equation

HRID 1993938 reaction equation
[C:1]12(C3C(=O)NN(C4C=CC=CN=4)C=3C)CC3CC(CC(C3)C1)C2.IC.[C:26]12([C:36]3[C:37](=[O:49])[NH:38][N:39]([C:42]4[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=4)[C:40]=3[CH3:41])[CH2:35][CH:30]3[CH2:31][CH:32]([CH2:34][CH:28]([CH2:29]3)[CH2:27]1)[CH2:33]2>>[C:26]12([C:36]3[C:37](=[O:49])[N:38]([CH3:1])[N:39]([C:42]4[CH:43]=[CH:44][C:45]([F:48])=[CH:46][CH:47]=4)[C:40]=3[CH3:41])[CH2:33][CH:32]3[CH2:34][CH:28]([CH2:29][CH:30]([CH2:31]3)[CH2:35]1)[CH2:27]2

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 160636344-Adamantan-1-yl-5-methyl-1-pyridin-2-yl-1,2-dihydro-pyrazol-3-oneHCID 686782474-Adamantan-1-yl-1-(4-fluoro-phenyl)-5-methyl-1,2-dihydro-pyrazol-3-one

Product 1

HCID 16063636HCID 16063636, compound

Procedure

This compound was obtained in two steps in analogy to example 62 and 61 using 4-fluorophenylhydrazine (example 62) and using iodomethane and 4-adamantan-1-yl-1-(4-fluoro-phenyl)-5-methyl-1,2-dihydro-pyrazol-3-one (example 61) to give 4-adamantan-1-yl-1-(4-fluoro-phenyl)-2,5-dimethyl-1,2-dihydro-pyrazol-3-one as a yellow solid. MS (ESI+): 341.3 [M+H]+).

Sources & evidence

ORD record
ord-be05aa205d61487f821d0cbb0976b5dc
Source dataset
uspto-grants-2010_01
Patent number
US07652057B2

Reaction notes

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