HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-nitro-2-(trifluoromethyl)benzoate → Methyl 4-amino-2-(trifluoromethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-nitro-2-(trifluoromethyl)benzoate | HCID 46311176 | — |
| Reactant | Tin tetrachloride dihydrate | HCID 85782573 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 4-amino-2-(trifluoromethyl)benzoate | HCID 46311081 | — |
Reaction Steps
Methyl 4-nitro-2-(trifluoromethyl)benzoate (5.20 g, 20.9 mmol) was dissolved in EtOAc (100 mL) and tin chloride dihydrate (9.41 g, 41.7 mmol) was added to the reaction mixture. The reaction was heated at reflux for 2 h. The crude reaction mixture was purified by column chromatography (SiO2, EtOAc/hexanes) to give the title compound. LCMS: (FA) ES− 218.4 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652041B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-5142fc929ec341fcbdd87482b31c9991 |
| Source note | uspto-grants-2010_01 |