反应详情

Methyl 4-nitro-2-(trifluoromethyl)benzoate (5.20 g, 20.9 mmol) was dissolved in EtOAc (100 mL) and tin chloride dihydrate (9.41 g, 41.7 mmol) was added to the reaction mixture. The reaction was heated at reflux for 2 h. The crude reaction mixture was purified by column chromatography (SiO2, EtOAc/hexanes) to give the title compound. LCMS: (FA) ES− 218.4 (M−1).

1. temperatureThe reaction was heated
2. temperatureat reflux for 2 h
3. customThe crude reaction mixture
4. customwas purified by column chromatography (SiO2, EtOAc/hexanes)