Methyl iodide → HCID 22574220, compound

HRID 1994218Notes

Reaction equation

HRID 1994218 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[F:21])[C:5]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]([Cl:17])[CH:11]=1)([OH:9])[C:6]([OH:8])=[O:7].[CH2:22]1CCN2C(=NCCC2)CC1.CI>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[F:21])[C:5]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]([Cl:17])[CH:11]=1)([OH:9])[C:6]([O:8][CH3:22])=[O:7]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 22574195HCID 22574195, compound

Product 1

HCID 22574220HCID 22574220, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

17.07 g (0.0512 mol) of 3,3′-dichloro-4,4′-difluorobenzilic acid, 14.10 g (0.0926 mol) of DBU, and 26.29 g (0.1852 mol) of methyl iodide are reacted in 200 ml acetonitrile analogously to step I.10.3. Yield: 6.77 g (38% of theory).

Sources & evidence

ORD record
ord-a91928795cd04ef79bbdbe94e206a825
Source dataset
uspto-grants-2010_01
Patent number
US07652138B2

Reaction notes

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