Chlorobenzilate → HCID 131727549, compound

HRID 1994220Notes

Reaction equation

[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)([OH:12])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:4][CH:3]=1.[C@@:22]12([OH:31])[N:29]([CH3:30])[C@@H:26]([CH2:27][CH2:28]1)[CH2:25][CH:24]=[CH:23]2>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[OH:12])=[CH:20][CH:21]=1.[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[OH:12])=[CH:20][CH:21]=1.[C@@:22]12([OH:31])[N:29]([CH3:30])[C@@H:26]([CH2:27][CH2:28]1)[CH2:25][CH:24]=[CH:23]2

Participants

Reactant 2

HCID 10522Chlorobenzilate

HCID 53629842Tropenol

Product 1

HCID 131727549HCID 131727549, compound

Procedure

4.3 is prepared analogously to the method according to II.1. Yield: 6.95 g (83% of theory) starting from 6.5 g (0.02 mol) of 3i and 2.78 g (0.02 mol) of tropenol; TLC: Rf value: 0.30 (eluant as in step I.1); melting point: 197° C.-199° C.

Workup

custom4.3 is prepared analogously to the method

Sources & evidence

ORD record: ord-27a924268bce48dcaac7dc481c81c76e
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07652138B2

Reaction notes

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