Thionyl Chloride → HCID 22266508, compound

HRID 1994277Notes

Reaction equation

HRID 1994277 reaction equation
[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([C:12](O)=[O:13])=[CH:8][C:7]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:6]1=2)[CH2:2][CH2:3][CH3:4].S(Cl)([Cl:23])=O>C1(C)C=CC=CC=1>[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([C:12]([Cl:23])=[O:13])=[CH:8][C:7]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:6]1=2)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22266520HCID 22266520, compound

Product 1

HCID 22266508HCID 22266508, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1-Butyl-2-oxo-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carboxylic acid (B-01) (416 mg, 1.50 mmol) was dissolved in toluene (15 ml), and to the reaction mixture was added thionyl chloride (328 μL, 4.50 mmol), and the reaction mixture was reacted at 65° C. for 20 min. The reaction mixture was evaporated under reduced pressure to give 1-butyl-2-oxo-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carbonyl chloride (B-02).

Workup

  1. customthe reaction mixture was reacted at 65° C. for 20 min
  2. customThe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-81bee688b4324da5a571411558d3a391
Source dataset
uspto-grants-2010_01
Patent number
US07652141B2

Reaction notes

Loading…