Potassium Carbonate → HCID 22145920, compound

HRID 1994355Notes

Reaction equation

HRID 1994355 reaction equation
C(=O)([O-])[O-].[K+].[K+].C([O:10][CH2:11][C:12]1[N:17]=[N:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=1)(=O)C>O.CO>[CH3:19][O:18][C:15]1[N:16]=[N:17][C:12]([CH2:11][OH:10])=[CH:13][C:14]=1[O:20][CH3:21]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 22145882HCID 22145882, compound

Product 1

HCID 22145920HCID 22145920, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

A solution of potassium carbonate (0.2 g) in water 2 mL) is added to a solution of 6-acetoxymethyl-3,4-dimethoxypyridazine (0.27 g) in methanol (6 mL) and the mixture stirred at 60-70° C. for 2 hours. After evaporating to dryness the residue is partitioned between ethyl acetate (10 mL) and brine (10 mL). The ethyl acetate phase is evaporated to dryness and the residue purified by flash chromatography (ethyl acetate as eluent on silica) to give 3,4-dimethoxy-6-hydroxymethylpyridazine as a white solid, m.p. 151-3° C.

Workup

  1. customAfter evaporating to dryness the residue
  2. customis partitioned between ethyl acetate (10 mL) and brine (10 mL)
  3. customThe ethyl acetate phase is evaporated to dryness
  4. customthe residue purified by flash chromatography (ethyl acetate as eluent on silica)

Sources & evidence

ORD record
ord-56993deb0535491e965854f7e0f9c467
Source dataset
uspto-grants-2010_01
Patent number
US07652144B2

Reaction notes

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