Sulfuric Acid → 3-[2,6-Dichloro-4-(3,3-dichloroallyloxy)-phenoxy]-propan-1-ol

HRID 1994381Notes

Reaction equation

HRID 1994381 reaction equation
Br[CH2:2][CH2:3][CH2:4][OH:5].[Cl:6][C:7]1[CH:12]=[C:11]([O:13][CH2:14][CH:15]=[C:16]([Cl:18])[Cl:17])[CH:10]=[C:9]([Cl:19])[C:8]=1[OH:20].[OH-].[Na+].S(=O)(=O)(O)O>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O.C1(C)C=CC=CC=1>[Cl:6][C:7]1[CH:12]=[C:11]([O:13][CH2:14][CH:15]=[C:16]([Cl:18])[Cl:17])[CH:10]=[C:9]([Cl:19])[C:8]=1[O:20][CH2:2][CH2:3][CH2:4][OH:5]

Participants

8

Reactant 4

HCID 1118Sulfuric AcidHCID 123083-Bromo-1-propanolHCID 14798Sodium HydroxideHCID 113467384-(3,3-Dichloro-2-propenyloxy)-2,6-dichlorophenol

Product 1

HCID 113139803-[2,6-Dichloro-4-(3,3-dichloroallyloxy)-phenoxy]-propan-1-olYield 99.9%

Reagents, catalysts & solvents 3

HCID 74236Tetrabutylammonium BromideCatalystHCID 962WaterSolventHCID 1140TolueneSolvent

Conditions

Temperature
60 °C

Procedure

To a mixture of 0.72 g of 3-bromopropanol, 1.0 g of 2,6-dichloro-4-(3,3-dichloro-2-propenyloxy)phenol, 5.0 g of toluene, 0.06 g of tetra-n-butylammonium bromide and 5.0 g of water was added 0.77 q of a 27% aqueous sodium hydroxide solution, The mixture was heated to 60° C. and stirred for 8 hours. The reaction mixture was then cooled to 20° C. After 2.0 g of a 20% aqueous sulfuric acid solution was added thereto, the mixture was stirred and then separated. The obtained organic layer was washed with 5.0 g of water and concentrated under reduced pressure to give 1.2 g of 3-(2,6-dichloro-4-(3,3-dichloro-2-propenyloxy)phenoxy)-1-propyl alcohol (purity: 92%, yield: 93%).

Workup

  1. temperatureThe reaction mixture was then cooled to 20° C
  2. stirringthe mixture was stirred
  3. customseparated
  4. washThe obtained organic layer was washed with 5.0 g of water
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-6b2eb37175264819ba3908cb20dd206d
Source dataset
uspto-grants-2010_01
Patent number
US07652177B2

Reaction notes

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