2-Fluoroethyl bromide → HCID 85990906, compound

HRID 1994425Notes

Reaction equation

HRID 1994425 reaction equation
[NH2:1][CH2:2][CH:3]([O:7][CH2:8][CH3:9])[O:4][CH2:5][CH3:6].Br[CH2:11][CH2:12][F:13].C(N(C(C)C)CC)(C)C>CCOCC>[CH2:5]([O:4][CH:3]([O:7][CH2:8][CH3:9])[CH2:2][NH:1][CH2:11][CH2:12][F:13])[CH3:6]

Participants

5

Reactant 3

HCID 129822-Fluoroethyl bromideHCID 695242,2-DiethoxyethylamineHCID 81531Diisopropylethylamine

Product 1

HCID 85990906HCID 85990906, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 3.1 ml (21.5 mmol) of 1-amino-2,2-diethoxyethane, 3.0 g (23.6 mmol) of 1-bromo-2-fluoroethane and 5.56 g (43 mmol) of diisopropylethylamine was heated at 100° C. in a closed vessel for 6 hours. The reaction mixture was diluted with ether and washed with 1N NaOH and water. The organic phase was dried (MgSO4) and concentrated in vacuo. The residue was distilled in vacuo. 1.3 g of substance were obtained as a clear liquid.

Workup

  1. washwashed with 1N NaOH and water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. concentrationconcentrated in vacuo
  4. distillationThe residue was distilled in vacuo
  5. custom1.3 g of substance were obtained as a clear liquid

Sources & evidence

ORD record
ord-9d77c5e7d7f1457881bb69c4f2333c33
Source dataset
uspto-grants-2010_01
Patent number
US07652007B2

Reaction notes

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