反应详情

To a solution of 2,6-difluoronitrobenzene (5 g, 32 mmol) in methanol (50 mL) was added potassium hydroxide (1.8 g, 32.5 mmol), and the mixture was heated to reflux for 3 hr. Water was added, and the mixture was extracted with dichloromethane. The organic layer was separated, dried, filtered, and evaporated to yield 5.1 g (95%) of 1-fluoro-3-methoxy-2-nitrobenzene, 1e. MS m/z (MH+) 172.

1. temperaturethe mixture was heated
2. temperatureto reflux for 3 hr
3. extractionthe mixture was extracted with dichloromethane
4. customThe organic layer was separated
5. customdried
6. filtrationfiltered
7. customevaporated