HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1-Fluoro-3-methoxy-2-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1,3-Difluoro-2-nitrobenzene | HCID 87922 | — |
| Product | 1-Fluoro-3-methoxy-2-nitrobenzene | HCID 2782776 | 95% |
Reaction Steps
To a solution of 2,6-difluoronitrobenzene (5 g, 32 mmol) in methanol (50 mL) was added potassium hydroxide (1.8 g, 32.5 mmol), and the mixture was heated to reflux for 3 hr. Water was added, and the mixture was extracted with dichloromethane. The organic layer was separated, dried, filtered, and evaporated to yield 5.1 g (95%) of 1-fluoro-3-methoxy-2-nitrobenzene, 1e. MS m/z (MH+) 172.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652005B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-4b12df4a7eea49bd87126316c26eb897 |
| Source note | uspto-grants-2010_01 |