(4-Fluoro-5-isopropyl-2-methoxyphenyl)boronic acid → 4′-Fluoro-2′-methoxy-5′-(1-methylethyl)-4-(trifluoromethyl)[1,1′-biphenyl]-2-carboxaldehyde

HRID 1994646Notes

Reaction equation

HRID 1994646 reaction equation
I[C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=1[CH:4]=[O:5].[F:14][C:15]1[C:20]([CH:21]([CH3:23])[CH3:22])=[CH:19][C:18](B(O)O)=[C:17]([O:27][CH3:28])[CH:16]=1>>[F:14][C:15]1[C:20]([CH:21]([CH3:23])[CH3:22])=[CH:19][C:18]([C:2]2[C:3]([CH:4]=[O:5])=[CH:6][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:8][CH:9]=2)=[C:17]([O:27][CH3:28])[CH:16]=1

Participants

3

Reactant 2

HCID 53363739(4-Fluoro-5-isopropyl-2-methoxyphenyl)boronic acidHCID 716509062-Iodo-5-(trifluoromethyl)benzaldehyde

Product 1

HCID 591352254′-Fluoro-2′-methoxy-5′-(1-methylethyl)-4-(trifluoromethyl)[1,1′-biphenyl]-2-carboxaldehyde

Procedure

Following the procedure described in EXAMPLE 81, 200 mg of 2-iodo-5-(trifluoromethyl)benzaldehyde (EXAMPLE 80, Step A) and 170 mg of (4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid (EXAMPLE 78) gave the title compound. Mass spectrum (ESI) 341.3 (M+1).

Sources & evidence

ORD record
ord-df032f5682264935a3a48260938f09d5
Source dataset
uspto-grants-2010_01
Patent number
US07652049B2

Reaction notes

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