HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Fluoro-5-isopropyl-2-methoxyphenyl)boronic acid → 4′-Fluoro-2′-methoxy-5′-(1-methylethyl)-4-(trifluoromethyl)[1,1′-biphenyl]-2-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Fluoro-5-isopropyl-2-methoxyphenyl)boronic acid | HCID 53363739 | — |
| Reactant | 2-Iodo-5-(trifluoromethyl)benzaldehyde | HCID 71650906 | — |
| Product | 4′-Fluoro-2′-methoxy-5′-(1-methylethyl)-4-(trifluoromethyl)[1,1′-biphenyl]-2-carboxaldehyde | HCID 59135225 | — |
Reaction Steps
Following the procedure described in EXAMPLE 81, 200 mg of 2-iodo-5-(trifluoromethyl)benzaldehyde (EXAMPLE 80, Step A) and 170 mg of (4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid (EXAMPLE 78) gave the title compound. Mass spectrum (ESI) 341.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652049B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-df032f5682264935a3a48260938f09d5 |
| Source note | uspto-grants-2010_01 |