4-([Bis-(4-benzyloxy-phenyl)-methyl]-[1,2,4]triazol-4-yl-amino}-benzonitrile → 4-([Bis-(4-hydroxy-phenyl)-methyl]-[1,2,4]triazol-4-yl-amino}-benzonitrile

HRID 19948Notes

Reaction equation

HRID 19948 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([N:30]([N:39]2[CH:43]=[N:42][N:41]=[CH:40]2)[C:31]2[CH:38]=[CH:37][C:34]([C:35]#[N:36])=[CH:33][CH:32]=2)[C:16]2[CH:21]=[CH:20][C:19]([O:22]CC3C=CC=CC=3)=[CH:18][CH:17]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd].C(OCC)(=O)C>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([N:30]([N:39]2[CH:43]=[N:42][N:41]=[CH:40]2)[C:31]2[CH:38]=[CH:37][C:34]([C:35]#[N:36])=[CH:33][CH:32]=2)[C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:11][CH:10]=1

Participants

5

Reactant 1

HCID 219768434-([Bis-(4-benzyloxy-phenyl)-methyl]-[1,2,4]triazol-4-yl-amino}-benzonitrile

Product 1

HCID 219768584-([Bis-(4-hydroxy-phenyl)-methyl]-[1,2,4]triazol-4-yl-amino}-benzonitrile

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

4-{[Bis-(4-benzyloxy-phenyl)-methyl]-[1,2,4]triazol-4-yl-amino}-benzonitrile (CAB02068, 564 mg, 1.0 mmol) was dissolved in ethanol, (50 mL) and palladium on charcoal (50 mg, 10% Pd) was added. The mixture was stirred under hydrogen atmosphere (balloon) for 48 h (TLC monitored) until all starting material was consumed. The Pd/C was filtered off (celite) and the solution was concentrated under reduced pressure. A yellow solid was obtained, which was dissolved in ethyl acetate (10 mL) upon heating. After cooling to room temperature the white precipitate was filtered off and dried under high vacuum. Yield: 312 mg (81%). 1H-NMR (400 MHz, d6-DMSO)=5.74 (s, 2H, 2×—OH); 6.28 (s, 1H), 6.53 (d, J=9.0 Hz, 2H), 6.61 (d, J=8.6 Hz, 4H), 7.10 (d, J=8.6 Hz, 4H), 7.65 (d, J=−9.0 Hz, 2H), 8.83 (s, 2H). LRMS (FAB+): 199.1 (100), 384.1 (50, [M+H]+). LRMS (FAB−) 184.1 (100), 382.1 (41, [M−H]−).

Workup

  1. customwas consumed
  2. filtrationThe Pd/C was filtered off (celite)
  3. concentrationthe solution was concentrated under reduced pressure
  4. customA yellow solid was obtained
  5. temperatureupon heating
  6. filtrationwas filtered off
  7. customdried under high vacuum

Sources & evidence

ORD record
ord-3221df03421548a28fcc756413a0a5ce
Source dataset
uspto-grants-2010_06
Patent number
US07745472B2

Reaction notes

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