Ethyl Acetate → 2-(Benzylthio)-3-thiomorpholinopropan-1-amine

HRID 1994859Notes

Reaction equation

HRID 1994859 reaction equation
[CH2:1]([S:8][CH:9]([CH2:19][N:20]1[CH2:25][CH2:24][S:23][CH2:22][CH2:21]1)[CH2:10][NH:11]C(=O)OC(C)(C)C)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OCC)(=O)C.C(OCC)(=O)C.Cl>CO>[CH2:1]([S:8][CH:9]([CH2:19][N:20]1[CH2:21][CH2:22][S:23][CH2:24][CH2:25]1)[CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 21866389Hydrogen chloride-ethyl acetateHCID 59135685Tert-butyl [2-(benzylthio)-3-thiomorpholinopropyl]carbamate

Product 1

HCID 574762142-(Benzylthio)-3-thiomorpholinopropan-1-amineYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl [2-(benzylthio)-3-thiomorpholinopropyl]carbamate (21.46 g) in a mixed solvent of ethyl acetate (60 mL) and methanol (60 mL) was added hydrogen chloride-ethyl acetate solution (120 mL) at 0° C., and the mixture was stirred at room temperature for 4 hr. The reaction solution was concentrated, and the residue was partitioned between ethyl acetate and saturated aqueous potassium carbonate solution. The organic layer was washed with saturated brine, and dried over sodium sulfate, and the solvent was evaporated to give the title compound (14.41 g, yield 91%) as a yellow oil.

Workup

  1. concentrationThe reaction solution was concentrated
  2. customthe residue was partitioned between ethyl acetate and saturated aqueous potassium carbonate solution
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over sodium sulfate
  5. customthe solvent was evaporated

Sources & evidence

ORD record
ord-4a9d5813bc294a0c94be85f505519060
Source dataset
uspto-grants-2010_01
Patent number
US07652133B2

Reaction notes

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