反应详情

A mixture of 1.0 g. of 2-chloro-5-phenylpyrazine, m.p. 98°-99° C., 5.0 ml. of pyridine and 5.0 ml. of hydrazine hydrate is heated at reflux for 1.5 hours. The solution is cooled, and 20 ml. of water is added. The colorless crystalline product is collected and air dried. The crude product is recrystallized from aqueous ethanol to yield 0.35 g. of the product of the example as colorless needles, m.p. 128°-130° C.

1. additionA mixture of 1.0 g
2. temperatureat reflux for 1.5 hours
3. temperatureThe solution is cooled
4. customThe colorless crystalline product is collected
5. customair dried
6. customThe crude product is recrystallized from aqueous ethanol
7. customto yield 0.35 g