反应详情

A mixture of 9 parts of ethyl N-(2,2-dimethoxyethyl)-N'-[4-(4-methoxyphenyl)-1-piperazinyl]carbamimidothioate monohydroiodide and 100 parts of a hydrochloric acid solution 6 N is stirred and refluxed for 1 hour. The reaction mixture is cooled and adjusted to pH 10 with a sodium hydroxide solution 30%. The product is extracted with dichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from 1,1'-oxybisbutane (activated charcoal), yielding 6 parts (100%) of 1-[2-(ethylthio)-1H-imidazol-1-yl]-4-(4-methoxyphenyl)piperazine; mp. 111.8° C.

1. temperaturerefluxed for 1 hour
2. temperatureThe reaction mixture is cooled
3. extractionThe product is extracted with dichloromethane
4. customThe extract is dried
5. filtrationfiltered
6. customevaporated
7. customThe residue is crystallized from 1,1'-oxybisbutane (activated charcoal)