Hydrochloric Acid → HCID 12952718, compound

HRID 1995074Notes

Reaction equation

HRID 1995074 reaction equation
I.CO[CH:4](OC)[CH2:5][NH:6][C:7]([S:23][CH3:24])=[N:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1.Cl.[OH-].[Na+]>>[CH3:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([N:12]2[CH2:13][CH2:14][N:9]([N:8]3[CH:4]=[CH:5][N:6]=[C:7]3[S:23][CH3:24])[CH2:10][CH2:11]2)=[CH:16][CH:17]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178491996HCID 178491996, compound

Product 1

HCID 12952718HCID 12952718, compoundYield 100%

Procedure

A mixture of 6 parts of methyl N-(2,2-dimethoxyethyl)-N'-[4-(4-methoxyphenyl)-1-piperazinyl]carbamimidothioate monohydroiodide and 30 parts of a hydrochloric acid solution 6 N is stirred and refluxed for 1 hour. The reaction mixture is cooled and adjusted to pH 10 with sodium hydroxide solution. The precipitated product is filtered off and crystallized from 4-methyl-2-pentanone, yielding 3.7 parts (100%) of 1-(4-methoxyphenyl)-4-[2-(methylthio)-1H-imidazol-1-yl]piperazine, mp. 140.1° C.

Workup

  1. temperaturerefluxed for 1 hour
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe precipitated product is filtered off
  4. customcrystallized from 4-methyl-2-pentanone

Sources & evidence

ORD record
ord-eba775da24104f248afc0bced51b0c95
Source dataset
uspto-grants-1983_09
Patent number
US04402957

Reaction notes

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