Potassium hydride → HCID 20489613, compound

HRID 1995091Notes

Reaction equation

HRID 1995091 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13]CC)=O)[CH:2]=1.[H-].[K+]>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11](=[O:13])[CH2:7][CH2:6][CH:5]2[CH2:4][CH2:3][CH2:2][NH:1][CH2:10]2)[CH:2]=1

Participants

3

Reactant 2

HCID 82127Potassium hydrideHCID 282842ethyl quinoline-3-carboxylate

Product 1

HCID 20489613HCID 20489613, compoundYield 100%

Procedure

The operation is as in Example 1, but starting from 4.5 g of ethyl quinoline-3-carboxylate, 6 g of ethyl 3-[3-(N-benzoyl)piperidyl]propionate and 13 ml of a 20% suspension of potassium hydride in oil. 3 g of crude 1-(3-quinolyl)-3-(3-piperidyl)-1-propanone are obtained.

Sources & evidence

ORD record
ord-7dffd8e299ad4c4ab0729ee8341a90ee
Source dataset
uspto-grants-1983_09
Patent number
US04402961

Reaction notes

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