Carbon Tetrachloride → HCID 86019929, compound

HRID 1995148Notes

Reaction equation

HRID 1995148 reaction equation
[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[NH2:6][CH2:7][C:8]1[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=1.[NH2:17][CH2:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:29].C(Cl)(Cl)(Cl)[Cl:35]>C(Cl)Cl>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[NH2:6][CH2:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([Cl:29])=[O:13])=[CH:10][CH:9]=1.[NH2:17][CH2:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([Cl:35])=[O:24])=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 5943Carbon TetrachlorideHCID 24819Phosphorus pentachlorideHCID 85529818HCID 85529818, compound

Product 1

HCID 86019929HCID 86019929, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Twenty grams of p-aminomethylbenzoic acid hemisulfate was suspended in 400 ml of methylene chloride, and 75 g of phosphorus pentachloride was slowly added to the suspension. The reaction was carried out at 40° to 45° C. for 2.5 hours. The solution was cooled with ice, and 300 ml of carbon tetrachloride was added, followed by filtration to give 18.3 g (yield 84%) of p-aminomethylbenzoyl chloride hemisulfate as white crystals.

Workup

  1. additionwas added
  2. filtrationfollowed by filtration

Sources & evidence

ORD record
ord-56f1ec8307e44327a7b9b38b440630c8
Source dataset
uspto-grants-1983_09
Patent number
US04402975

Reaction notes

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