Methanol → 2-Methoxy-1-formylpiperidine

HRID 1995270Notes

Reaction equation

HRID 1995270 reaction equation
[CH:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)=[O:2].[CH3:9][OH:10]>F[B-](F)(F)F.C[N+](C)(C)C>[CH:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[O:10][CH3:9])=[O:2]

Participants

4

Reactant 2

HCID 887MethanolHCID 174291-Piperidinecarboxaldehyde

Product 1

HCID 27236672-Methoxy-1-formylpiperidineYield 95%

Reagents, catalysts & solvents 1

HCID 12621Tetramethylammonium tetrafluoroborateCatalyst

Procedure

In the cell and device as described in Example 2 a mixture of 480 g of 1-formylpiperidine, 1,360 g of methanol and 6.80 g of tetramethylammonium tetrafluoroborate was electrolyzed for 34 hours and 15 minutes at 1 A (corresponding to 240 Ahr), 98 volts and 25° C. By distillative work up, 577 g of 1-formyl-2-methoxypiperidine could be isolated from the clear electrolyte, corresponding to a current efficiency of 90.2% of the theory.

Workup

  1. customA (corresponding to 240 Ahr), 98 volts and 25° C

Sources & evidence

ORD record
ord-4f132cc8c90c40abaee0ba130d69ab50
Source dataset
uspto-grants-1983_09
Patent number
US04404082

Reaction notes

Loading…