3-(2-Chloroethyl)-3-azabicyclo[3.2.2]nonane--hydrogen chloride (1/1) → HCID 13189014, compound

HRID 1995289Notes

Reaction equation

HRID 1995289 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]2[C:9]3[CH2:14][CH2:13][NH:12][CH2:11][C:10]=3[C:15](=[O:17])[O:16][C:5]=2[CH:4]=1)[CH3:2].[ClH:18].[Cl:19][CH2:20][CH2:21][N:22]1[CH2:28][CH:27]2[CH2:29][CH2:30][CH:24]([CH2:25][CH2:26]2)[CH2:23]1>>[ClH:19].[ClH:18].[CH:27]12[CH2:29][CH2:30][CH:24]([CH2:25][CH2:26]1)[CH2:23][N:22]([CH2:21][CH2:20][N:12]1[CH2:13][CH2:14][C:9]3[C:6]4[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[CH:4][C:5]=4[O:16][C:15](=[O:17])[C:10]=3[CH2:11]1)[CH2:28]2

Participants

3

Reactant 2

HCID 126123263-(2-Chloroethyl)-3-azabicyclo[3.2.2]nonane--hydrogen chloride (1/1)HCID 131369198-Ethyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one

Product 1

HCID 13189014HCID 13189014, compoundYield 68%

Procedure

Prepared by the method described for Example 1 from 8-ethyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one (5.5 g, 0.024 moles) and 3-(2-chloroethyl)-3-azabicyclo(3.2.2)nonane hydrochloride (5.5 g, 0.025 moles). Recrystallization from ethanol gave the product (7.4 g), mp 295°-300° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-9f876a4f8ea84952bc05cdb19253cd63
Source dataset
uspto-grants-1983_09
Patent number
US04404138

Reaction notes

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