HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Chloroethyl)-3-azabicyclo[3.2.2]nonane--hydrogen chloride (1/1) → 3-[2-(3-Azabicyclo[3.2.2]non-3-yl)ethyl]-1,2,3,4-tetrahydro-8-phenyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one, dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Chloroethyl)-3-azabicyclo[3.2.2]nonane--hydrogen chloride (1/1) | HCID 12612326 | — |
| Reactant | 8-Phenyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one | HCID 13136920 | — |
| Product | 3-[2-(3-Azabicyclo[3.2.2]non-3-yl)ethyl]-1,2,3,4-tetrahydro-8-phenyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one, dihydrochloride | HCID 13189016 | 9.2% |
Reaction Steps
Prepared by the method described for Example 1 from 8-phenyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one (5.54 g, 0.02 moles) and 3-(2-chloroethyl)-3-azabicyclo(3.2.2)nonane hydrochloride (4.48 g, 0.02 moles). Recrystallization from methanol gave the product (920 mg), mp 260°-265° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04404138 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-bf2c665a26ac4c76a6ecf4ad6fd56e38 |
| Source note | uspto-grants-1983_09 |