Hydrogen Bromide → HCID 13189032, compound

Participants

Reaction Steps

A solution of 3-[2-(3-azabicyclo[3.2.2]non-3-yl)ethyl]-1,2,3,4-tetrahydro-8,9-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one dihydrochloride (10.0 g, 0.020 moles) and 48% aqueous hydrobromic acid (100 ml) is stirred at reflux for 16 hours. The dihydrobromide product (10.7 g) is used as an intermediate without additional purification. A sample recrystallized from aqueous methanol/N,N-dimethylformamide had mp 270° C. (dec).

Provenance & Evidence