Hydrogen Bromide → HCID 13189032, compound

HRID 1995301Notes

Reaction equation

HRID 1995301 reaction equation
Cl.Cl.[CH:3]12[CH2:11][CH2:10][CH:7]([CH2:8][CH2:9]1)[CH2:6][N:5]([CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][C:17]3[C:20]4[CH:28]=[C:27]([O:29]C)[C:26]([O:31]C)=[CH:25][C:21]=4[O:22][C:23](=[O:24])[C:16]=3[CH2:15]1)[CH2:4]2.[BrH:33]>>[BrH:33].[BrH:33].[CH:3]12[CH2:11][CH2:10][CH:7]([CH2:8][CH2:9]1)[CH2:6][N:5]([CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][C:17]3[C:20]4[CH:28]=[C:27]([OH:29])[C:26]([OH:31])=[CH:25][C:21]=4[O:22][C:23](=[O:24])[C:16]=3[CH2:15]1)[CH2:4]2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 13189026HCID 13189026, compound

Product 1

HCID 13189032HCID 13189032, compound

Procedure

A solution of 3-[2-(3-azabicyclo[3.2.2]non-3-yl)ethyl]-1,2,3,4-tetrahydro-8,9-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one dihydrochloride (10.0 g, 0.020 moles) and 48% aqueous hydrobromic acid (100 ml) is stirred at reflux for 16 hours. The dihydrobromide product (10.7 g) is used as an intermediate without additional purification. A sample recrystallized from aqueous methanol/N,N-dimethylformamide had mp 270° C. (dec).

Workup

  1. temperatureat reflux for 16 hours
  2. customThe dihydrobromide product (10.7 g) is used as an intermediate without additional purification
  3. customA sample recrystallized from aqueous methanol/N,N-dimethylformamide

Sources & evidence

ORD record
ord-63334a5728664b1e8d4fe76c2f704d0d
Source dataset
uspto-grants-1983_09
Patent number
US04404138

Reaction notes

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