HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-[2-(3-Azabicyclo[3.3.1]non-3-yl)ethyl]-1,2,3,4-tetrahydro-8-methoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 8-Methoxy-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one | HCID 13136918 | — |
| Reactant | 3-(2-Chloroethyl)-3-azabicyclo[3.3.1]nonane hydrochloride | HCID 20488143 | — |
| Product | 3-[2-(3-Azabicyclo[3.3.1]non-3-yl)ethyl]-1,2,3,4-tetrahydro-8-methoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one | HCID 13189035 | 48.3% |
Reaction Steps
Prepared by the method described for Example 13 from 1,2,3,4-tetrahydro-8-methoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one (3.0 g, 0.013 moles), triethylamine (7.2 ml, 0.052 moles), and 3-(2-chloroethyl)-3-azabicyclo-[3.3.1]nonane hydrochloride (3.25 g, 0.015 moles). Recrystallization from ethanol gave the product (2.4 g), mp 102°-103° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04404138 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-478b1e82b75e4d5dadc28725b650cea6 |
| Source note | uspto-grants-1983_09 |