反应详情

Prepared by the method described for Example 13 from 1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one (0.8 g, 0.004 moles), triethylamine (1.3 ml, 0.009 moles), and 3-(2-chloroethyl)-3-azabicyclo[3.3.1]nonane hydrochloride (1.0 g, 0.0045 moles). The reflux time is 72 hours. The crude product is triturated in 10% aqueous potassium carbonate, filtered off, rinsed with water, and dried to give the product (0.5 g), mp 129°-130° C.

1. customPrepared by the method
2. customThe crude product is triturated in 10% aqueous potassium carbonate
3. filtrationfiltered off
4. washrinsed with water
5. customdried