Ammonium Hydroxide → HCID 12210260, compound

HRID 1995313Notes

Reaction equation

HRID 1995313 reaction equation
[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:6]2=[N:5][CH:4]=[C:3]1[C:13]([O:15]CC)=O.[OH-].[NH4+:19]>>[C:13]([C:3]1[C:2](=[O:1])[N:7]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:6]2=[N:5][CH:4]=1)(=[O:15])[NH2:19]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 12778916HCID 12778916, compound

Product 1

HCID 12210260HCID 12210260, compoundYield 97.5%

Procedure

11.8 g. of ethyl 4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine-3-carboxylate are dissolved in 40 ml. of 30% by wieght ammonium hydroxide solution and the reaction mixture is allowed to stand at room temperature for 2 hours. The precipitated crystals are filtered and washed with water. 10.1 g. (97.5%) of 3-carbamoyl-4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine are obtained melting at 234°-235° C.

Workup

  1. filtrationThe precipitated crystals are filtered
  2. washwashed with water

Sources & evidence

ORD record
ord-744bd44d0c32449e92ce52d654726e7c
Source dataset
uspto-grants-1983_09
Patent number
US04404205

Reaction notes

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