Hydrazine hydrate (1:1) → HCID 13066353, compound

HRID 1995314Notes

Reaction equation

HRID 1995314 reaction equation
[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:6]2=[N:5][CH:4]=[C:3]1[C:13]([O:15]CC)=O.O.[NH2:19][NH2:20]>>[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:6]2=[N:5][CH:4]=[C:3]1[C:13]([NH:19][NH2:20])=[O:15]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12778916HCID 12778916, compound

Product 1

HCID 13066353HCID 13066353, compoundYield 81%

Procedure

A solution of 2.36 g. of ethyl 4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine-3-carboxylate in 10 ml. of 98% by W/V hydrazine hydrate is allowed to stand at room temperature for 2 hours. The precipitated crystals are filtered and washed with water and ethanol. 1.8 g. of (81%) 4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine-3-carbohydrazide are obtained melting at 184°-186° C.

Workup

  1. filtrationThe precipitated crystals are filtered
  2. washwashed with water and ethanol

Sources & evidence

ORD record
ord-e9137ef7f0824f3a9feda7e00c132227
Source dataset
uspto-grants-1983_09
Patent number
US04404205

Reaction notes

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