反应详情

A solution of 15.0 g (64 mmol) of 1,4-dihydro-8-nitro-4-oxo-3-quinolinecarboxylic acid [J. Amer. Chem. Soc. 68, 1264 (1946)] in 300 ml of dimethylformamide is hydrogenated using 1 g of Raney nickel catalyst at 51 psi and 23° C. until the required amount of hydrogen uptake is obtained. The catalyst is filtered off and the filtrate is concentrated to 50 ml and ethanol is added. The solid is collected by filtration and washed with ethanol and ether to give 9.7 g of the title compound.

1. customat 51 psi and 23° C.
2. customis obtained
3. filtrationThe catalyst is filtered off
4. concentrationthe filtrate is concentrated to 50 ml and ethanol
5. additionis added
6. filtrationThe solid is collected by filtration
7. washwashed with ethanol and ether