反应详情

A mixture of 2,3-dihydro-3-oxo-6-phenyl-4-pyridazinecarboxylic acid (1.92 g) ethyl chloroformate (1.1 g) and triethylamine (2.0 ml) in 50 ml of dichloromethane is allowed to stir at 25°-30° C. for 2 hours. Ammonia gas is then bubbled into the mixture for 15 minutes. Water (50 ml) is added and the dichloromethane is separated and concentrated on the rotary evaporator. The residue is chromatographed on silica gel with 2% methanol and chloroform to give 2,3-dihydro-3-oxo-6-phenyl-4-pyridazinecarboxamide.

1. customAmmonia gas is then bubbled into the mixture for 15 minutes
2. additionWater (50 ml) is added
3. customthe dichloromethane is separated
4. concentrationconcentrated on the rotary evaporator
5. customThe residue is chromatographed on silica gel with 2% methanol and chloroform