6-Chloropicolinic acid → HCID 178522668, compound

HRID 1995356Notes

Reaction equation

HRID 1995356 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[CH:4][CH:3]=1.S(Cl)(Cl)=O.[NH2:15][C:16]1[NH:20][N:19]=[N:18][N:17]=1>>[NH:17]1[C:16]([NH:15][C:8]([C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Cl:1])[N:7]=2)=[O:10])=[N:20][N:19]=[N:18]1

Participants

4

Reactant 3

HCID 208126-Chloropicolinic acidHCID 24386Thionyl ChlorideHCID 178509299HCID 178509299, compound

Product 1

HCID 178522668HCID 178522668, compoundYield 25.9%

Procedure

0.46 g of 6-chloro-2-pyridinecarboxylic acid, 15 ml of thionyl chloride and 0.29 g of 5-aminotetrazole are treated in the same manner as described in Example 1. The crude product thus obtained is recrystallized from a mixture of dimethylformamide and water, whereby 0.17 g of N-(5-tetrazolyl)-6-chloro-2-pyridinecarboxamide is obtained.

Workup

  1. customThe crude product thus obtained
  2. customis recrystallized from a mixture of dimethylformamide and water

Sources & evidence

ORD record
ord-f99068c1b0ab44e9a29c5a15a006197f
Source dataset
uspto-grants-1983_09
Patent number
US04404214

Reaction notes

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