4-Butylpyridine-2-carboxylic acid → HCID 178441156, compound

HRID 1995365Notes

Reaction equation

HRID 1995365 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]([OH:13])=O)[CH:6]=1)[CH2:2][CH2:3][CH3:4].[NH2:14][C:15]1[NH:19][N:18]=[N:17][N:16]=1>>[NH:16]1[C:15]([NH:14][C:11]([C:7]2[CH:6]=[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH:10]=[CH:9][N:8]=2)=[O:13])=[N:19][N:18]=[N:17]1

Participants

3

Reactant 2

HCID 132095594-Butylpyridine-2-carboxylic acidHCID 178509299HCID 178509299, compound

Product 1

HCID 178441156HCID 178441156, compoundYield 63%

Procedure

0.52 g of 4-n-butyl-2-pyridinecarboxylic acid, 0.48 g of N,N'-carbonyldiimidazole and 0.27 g of 5-aminotetrazole are treated in the same manner as described in Example 2. The crude product thus obtained is recrystallized from a mixture of dimethylformamide, water and ethanol, whereby 0.45 g of N-(5-tetrazolyl)-4-n-butyl-2-pyridinecarboxamide is obtained.

Workup

  1. customThe crude product thus obtained
  2. customis recrystallized from a mixture of dimethylformamide, water and ethanol

Sources & evidence

ORD record
ord-4798a0998e9a4c519002ef43ad901bc9
Source dataset
uspto-grants-1983_09
Patent number
US04404214

Reaction notes

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