4-Chloro-6-methylpyridine-2-carboxylic acid → HCID 178426117, compound

HRID 1995375Notes

Reaction equation

HRID 1995375 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]([OH:11])=O)[CH:3]=1.[NH2:12][C:13]1[NH:17][N:16]=[N:15][N:14]=1>>[NH:14]1[C:13]([NH:12][C:9]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([CH3:8])[N:5]=2)=[O:11])=[N:17][N:16]=[N:15]1

Participants

3

Reactant 2

HCID 114010234-Chloro-6-methylpyridine-2-carboxylic acidHCID 178509299HCID 178509299, compound

Product 1

HCID 178426117HCID 178426117, compoundYield 68.7%

Procedure

0.68 g of 4-chloro-6-methyl-2-pyridinecarboxylic acid, 0.67 g of N,N'-carbonyldiimidazole and 0.37 g of 5-aminotetrazole are treated in the same manner as described in Example 2. The crude product thus obtained is recrystallized from a mixture of dimethylformamide and ethanol, whereby 0.65 g of N-(5-tetrazolyl)-4-chloro-6-methyl-2-pyridinecarboxamide is obtained.

Workup

  1. customThe crude product thus obtained
  2. customis recrystallized from a mixture of dimethylformamide and ethanol

Sources & evidence

ORD record
ord-a4cc4b8d7f424794ad10242e96356b48
Source dataset
uspto-grants-1983_09
Patent number
US04404214

Reaction notes

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