Methanol → Benzoic acid, 2-chloro-6-nitro-, methyl ester

HRID 1995394Notes

Reaction equation

HRID 1995394 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[C:3]=1[C:4](Cl)=[O:5].[CH3:14][OH:15]>>[CH3:14][O:15][C:4](=[O:5])[C:3]1[C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:2]=1[Cl:1]

Participants

3

Reactant 2

HCID 887MethanolHCID 22596843HCID 22596843, compound

Product 1

HCID 603613Benzoic acid, 2-chloro-6-nitro-, methyl ester

Procedure

18.9 gm (86 mmols) of 2-chloro-6-nitro-benzoic acid chloride were added dropwise over a period of 10 minutes to 100 ml of methanol. The reaction mixture was refluxed for 4 hours and then evaporated in vacuo. The residue was treated with a little ice-cold methanol and filtered off.

Workup

  1. temperatureThe reaction mixture was refluxed for 4 hours
  2. customevaporated in vacuo
  3. additionThe residue was treated with a little ice-cold methanol
  4. filtrationfiltered off

Sources & evidence

ORD record
ord-b0b3036c90754a2ca210b4863c2ba8d6
Source dataset
uspto-grants-1983_09
Patent number
US04404230

Reaction notes

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