Hydrochloric Acid → HCID 20134489, compound

HRID 1995408Notes

Reaction equation

HRID 1995408 reaction equation
[NH2:1][C:2]1[C:15]([Cl:16])=[CH:14][C:5]([CH:6]([OH:13])[CH2:7][NH:8]C(C)(C)C)=[CH:4][C:3]=1[Cl:17].Cl.[CH3:19]O>>[ClH:16].[NH2:1][C:2]1[C:15]([Cl:16])=[CH:14][C:5]([CH:6]([O:13][CH3:19])[CH2:7][NH2:8])=[CH:4][C:3]=1[Cl:17]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2783Clenbuterol

Product 1

HCID 20134489HCID 20134489, compound

Procedure

In 100 ml of methanol, 10 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol is stirred in an ice bath and dry HCl gas is introduced into the solution. After saturation of the solution, the mixture is stirred at room temperature for an hour and evaporated to dryness. The solid is then stirred in ethyl acetate to afford the title product, which is collected by filtration.

Workup

  1. customevaporated to dryness
  2. stirringThe solid is then stirred in ethyl acetate

Sources & evidence

ORD record
ord-3f774ab66d604e1abf5fe3b6c4f1a6cc
Source dataset
uspto-grants-1983_09
Patent number
US04404222

Reaction notes

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