2-(Methylamino)ethanol → HCID 20488604, compound

HRID 1995431Notes

Reaction equation

HRID 1995431 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[CH3:12][NH:13][CH2:14][CH2:15][OH:16]>CO>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([NH:6][C:7]([N:13]([CH3:12])[CH2:14][CH2:15][OH:16])=[O:9])=[C:4]([OH:8])[CH:3]=1

Participants

4

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 298586-Chloro-2,3-dihydrobenzoxazol-2-one

Product 1

HCID 20488604HCID 20488604, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
65 °C

Procedure

6-Chlorobenzoxazolinone (20 g) and N-methylethanolamine (17.7 g) in methanol (40 ml) were stirred and heated at 65° C. for 3 hours. The mixture was cooled to ambient temperature, filtered, and the residue was washed with diethyl ether to give the desired urea which melted at 178° C. (decomp.).

Workup

  1. temperatureThe mixture was cooled to ambient temperature
  2. filtrationfiltered
  3. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-60525ab3d8d84893a60097471cfd8c07
Source dataset
uspto-grants-1983_09
Patent number
US04404356

Reaction notes

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