Isobutyraldehyde → HCID 21591647, compound

HRID 1995434Notes

Reaction equation

HRID 1995434 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][NH2:6].[CH:7](=O)[CH:8]([CH3:10])[CH3:9].C1CCCCC1>O>[CH3:1][N:2]1[CH2:3][CH2:4][CH2:5][NH:6][CH:7]1[CH:8]([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 6561IsobutyraldehydeHCID 8078CyclohexaneHCID 80511N-Methyl-1,3-propanediamine

Product 1

HCID 21591647HCID 21591647, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

530 g of N-methyl-1,3-diaminopropane are slowly added dropwise to a mixture of 650 ml of isobutyraldehyde and 400 ml of cyclohexane cooled with ice. When the exothermic reaction has died down, the reaction mixture is boiled under reflux on a water separator until approximately 108 ml of water have been separated. Cyclohexane and isobutyraldehyde are distilled off at reduced pressure. Fractional distillation of the residue (b.p.15 : 68° to 75° C.) yields 680 g of 1-methyl-2-isopropylhexahydropyrimidine.

Workup

  1. temperaturecooled with ice
  2. customWhen the exothermic reaction
  3. customhave been separated
  4. distillationCyclohexane and isobutyraldehyde are distilled off at reduced pressure
  5. distillationFractional distillation of the residue (b.p.15 : 68° to 75° C.)

Sources & evidence

ORD record
ord-13a1a3d019d043ca865d0141969e74b7
Source dataset
uspto-grants-1983_09
Patent number
US04404379

Reaction notes

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