Isobutyraldehyde → HCID 21591647, compound

Participants

Reaction Steps

530 g of N-methyl-1,3-diaminopropane are slowly added dropwise to a mixture of 650 ml of isobutyraldehyde and 400 ml of cyclohexane cooled with ice. When the exothermic reaction has died down, the reaction mixture is boiled under reflux on a water separator until approximately 108 ml of water have been separated. Cyclohexane and isobutyraldehyde are distilled off at reduced pressure. Fractional distillation of the residue (b.p.15 : 68° to 75° C.) yields 680 g of 1-methyl-2-isopropylhexahydropyrimidine.

Provenance & Evidence