Hydrogen Bromide → HCID 20487155, compound

HRID 1995581Notes

Reaction equation

HRID 1995581 reaction equation
[F:1][CH2:2][C:3]([N:14]1[C:18](=[O:19])[C:17]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:16]2[C:15]1=[O:24])([CH2:8][C:9](=[O:13])[CH:10]=[N+]=[N-])[C:4]([O:6][CH3:7])=[O:5].[BrH:25]>CCOCC>[F:1][CH2:2][C:3]([N:14]1[C:18](=[O:19])[C:17]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:16]2[C:15]1=[O:24])([CH2:8][C:9](=[O:13])[CH2:10][Br:25])[C:4]([O:6][CH3:7])=[O:5]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 54489450HCID 54489450, compound

Product 1

HCID 20487155HCID 20487155, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of methyl 2-fluoromethyl-2-phthalimido-4-oxo-5-diazo-pentanoate (1.53 g, 4.62 mmol) in ether (22.5 ml) is added dropwise and with vigorous stirring to cold (ice cooling) aqueous HBr (47%, 0.95 ml). Stirring is continued for 1 hour at room temperature. The organic phase is separated, washed with water, dried, and evaporated to give the title compound as a yellow oil (1.52 g).

Workup

  1. customThe organic phase is separated
  2. washwashed with water
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-a7f24fed4bdb4821a97f1a4923972fef
Source dataset
uspto-grants-1983_09
Patent number
US04405530

Reaction notes

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