HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorobenzoyl isocyanate → 1-(2,6-Difluorobenzoyl)-3-(5-(4-chlorophenyl)-2-pyridyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorobenzoyl isocyanate | HCID 2733369 | — |
| Reactant | 5-(4-Chlorophenyl)pyridin-2-amine | HCID 13242644 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(2,6-Difluorobenzoyl)-3-(5-(4-chlorophenyl)-2-pyridyl)urea | HCID 13242648 | — |
Reaction Steps
5-(4-Chlorophenyl)-2-pyridylamine (2 grams) was dissolved in 90 ml acetonitrile and then reacted with 2,6-difluorobenzoyl isocyanate (2.6 grams) under nitrogen at room temperature. A solid formed immediately which, after stirring for about 15 hours, was collected and identified as the desired product by NMR analysis, yield 3.4 grams, m.p. 229°-234° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04405552 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-0b5b8ff7de3449548a079dc82bdc993c |
| Source note | uspto-grants-1983_09 |