反应详情

3,4-Dihydro-6-methyl-5-phenyl-2(1H)-pyridone (25.6 grams) and 5% palladium/on carbon (4.9 grams) were refluxed for about 18 hours in 750 ml p-cymene. Since little product formed upon cooling, the reaction mixture was boiled and distilled until a constant temperature of 173° C. was reached. Refluxing continued for 36 hours and then the reaction mixture was filtered hot. Upon cooling, a solid precipitate formed which was collected and washed with ether, yield 13.0 grams, m.p. 201°-208° C.

1. customSince little product formed
2. temperatureupon cooling
3. distillationdistilled until a constant temperature of 173° C.
4. temperatureRefluxing
5. filtrationthe reaction mixture was filtered hot
6. temperatureUpon cooling
7. customa solid precipitate formed which
8. customwas collected
9. washwashed with ether, yield 13.0 grams, m.p. 201°-208° C.