HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 4-Methyl-5-[4-(piperidin-1-yl)benzoyl]-1,3-dihydro-2H-imidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-(4-Fluorobenzoyl)-5-methyl-1,3-dihydro-2H-imidazol-2-one | HCID 15567539 | — |
| Product | 4-Methyl-5-[4-(piperidin-1-yl)benzoyl]-1,3-dihydro-2H-imidazol-2-one | HCID 15567551 | — |
Reaction Steps
A suspension of 11.0 g (0.05 mole) of 1,3-dihydro-4-(4-fluorobenzoyl)-5-methyl-2H-imidazol-2-one in 30 ml of piperidine is stirred at reflux temperature for 24 hours. Excess piperidine is evaporated under reduced pressure and the residue is recrystallized twice from a mixture of isopropanol and water to give 11.9 g of the title compound. M.P. 260°-263° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04405635 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-74f30b4d680840ecaf16c01013bf3750 |
| Source note | uspto-grants-1983_09 |