反应详情

A suspension of 11.0 g (0.05 mole) of 1,3-dihydro-4-(4-fluorobenzoyl)-5-methyl-2H-imidazol-2-one in 30 ml of piperidine is stirred at reflux temperature for 24 hours. Excess piperidine is evaporated under reduced pressure and the residue is recrystallized twice from a mixture of isopropanol and water to give 11.9 g of the title compound. M.P. 260°-263° C.

1. temperatureat reflux temperature for 24 hours
2. customExcess piperidine is evaporated under reduced pressure
3. customthe residue is recrystallized twice from a mixture of isopropanol and water