Methyl Acrylate → HCID 12903398, compound

HRID 1995694Notes

Reaction equation

HRID 1995694 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:7]=[C:8]([O:10][CH3:11])[CH:9]=1)[NH2:6].[C:12]([O:16][CH3:17])(=[O:15])[CH:13]=[CH2:14]>C(O)(=O)C>[CH3:11][O:10][C:8]1[CH:7]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[CH:9]=1)[NH:6][CH2:14][CH2:13][C:12]([O:16][CH3:17])=[O:15]

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 663013,5-Dimethoxyaniline

Product 1

HCID 12903398HCID 12903398, compoundYield 73.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 3,5-dimethoxyaniline (114.9 g., 0.75 mole), methyl acrylate (69.73 g., 0.81 mole) and glacial acetic acid (2 ml.) is refluxed for 20 hours. Reflux is discontinued and the reaction mixture is concentrated and then distilled in vacuo, to yield 106.8 g. (73.9%) of the title product, b.p. 174°-179° C. (0.7 mm.).

Workup

  1. temperatureis refluxed for 20 hours
  2. temperatureReflux
  3. concentrationthe reaction mixture is concentrated
  4. distillationdistilled in vacuo
  5. customto yield 106.8 g

Sources & evidence

ORD record
ord-e4bf12e6085a4e839e4d1a2358aace1f
Source dataset
uspto-grants-1983_09
Patent number
US04405626

Reaction notes

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