Sodium Hydroxide → HCID 3062229, compound

HRID 1995751Notes

Reaction equation

HRID 1995751 reaction equation
ClC1[CH:3]=[C:4]2C(=CC=1)NC=[C:5]2[CH2:11][CH2:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.[OH-].[Na+].[C:21]1([NH2:32])[C:26](F)=[C:25](F)[C:24](F)=[C:23](N)[C:22]=1F.[ClH:33].[ClH:34]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)(Cl)Cl.O>[Cl:33][C:4]1[CH:3]=[N:32][C:21]2[C:22]([C:5]=1[CH2:11][CH2:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[CH:23][C:24]([Cl:34])=[CH:25][CH:26]=2

Participants

7

Reactant 3

HCID 14798Sodium HydroxideHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 12674078HCID 12674078, compound

Product 1

HCID 3062229HCID 3062229, compound

Reagents, catalysts & solvents 3

HCID 66133Benzyl triethylammonium chlorideCatalystHCID 962WaterSolventHCID 6212ChloroformSolvent

Procedure

The operation is as in Example 1, but starting from 11 g of 4-[2-(5-chloro-3-indolyl)-ethyl]-piperidine and 0.21 g of benzyltriethylammonium chloride in suspension in 100 ml of chloroform and 12.5 g of sodium hydroxide in solution in 25 ml of water. 2 g of 3,6-dichloro-4-[2-(4-piperidyl)-ethyl]-quinoline are finally obtained in the form of the dihydrochloride melting at 248° C.

Sources & evidence

ORD record
ord-37577a75db154fe48bd5229c1616fde0
Source dataset
uspto-grants-1983_09
Patent number
US04405789

Reaction notes

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